ich improve content uniformity by milling
Particle Size Specifications for Solid Oral Dosage Forms: A .May 1, 2010 . For the drug substance, the International Conference on Harmonization (ICH) guideline Q6A provides . content uniformity, stability, or product appearance) or drug product . while milling and grinding are related to particle size reduction. . which can improve both flow and compression characteristics .ich improve content uniformity by milling,Case Study - ICHAssay and content uniformity ... Lower water content, temperature and hold times will not increase hydrolytic . Add air attrition milling of seed to lower the.Influence of Process and Formulation Parameters on Dissolution .Nov 1, 2014 . Moreover, the content uniformity of the extrudates, unlike the . in the industry to improve the solubility and/or dissolution rate of such BCS . can be cut as tablets and pellets or milled into powder as desired. . This method was validated according to ICH and FDA guidelines for chromatographic methods.